Motif ID: HOX{A5,B5}.p2

Z-value: 1.538


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v1_chr17_-_46671322_466714120.446.4e-05Click!
HOXA5hg19_v1_chr7_-_27183225_271832860.291.2e-02Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_189026401 19.039 NM_173553
TRIML2
tripartite motif family-like 2
chr9_-_112970412 17.799 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr11_-_2018885 12.806 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr11_-_2019007 12.726 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018446 8.872 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr7_-_99381703 8.799 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr11_-_2018334 7.827 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr15_-_75017710 6.855 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr5_+_133842276 6.798


chr11_-_2018568 6.248 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr3_-_196065243 5.938 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr5_+_159614373 5.372 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr6_-_24877453 5.102 NM_015864
FAM65B
family with sequence similarity 65, member B
chr1_-_31230594 4.263 LAPTM5
lysosomal protein transmembrane 5
chr19_+_51152634 4.078 NM_001195076
C19orf81
chromosome 19 open reading frame 81
chr1_-_31230673 3.940 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr11_+_66395733 3.792


chr11_-_2018703 3.671 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_125648704 3.651 NM_212555
PATE2
prostate and testis expressed 2
chr11_+_74862031 3.538 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr20_+_42984088 3.393 HNF4A
hepatocyte nuclear factor 4, alpha
chr19_-_42636559 3.348 NM_001207025
NM_001207026
NM_001247994
NM_002698
POU2F2



POU class 2 homeobox 2



chr12_+_54955226 3.314 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr17_+_73629513 3.296 NM_001162995
C17orf109
chromosome 17 open reading frame 109
chr19_-_53757940 3.292 ZNF677
zinc finger protein 677
chr3_-_195538699 3.272 NM_004532
NM_018406
NM_138297
MUC4


mucin 4, cell surface associated


chr6_-_31981049 3.264 NM_032470
TNXB
tenascin XB
chr1_+_4714668 3.245 AJAP1
adherens junctions associated protein 1
chr4_-_149363498 3.228 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr1_-_149785235 3.169 NM_001123375
HIST2H3D
histone cluster 2, H3d
chr10_+_52750930 3.151 PRKG1
protein kinase, cGMP-dependent, type I
chr6_-_97285058 3.150 NM_001143957
NM_030784
GPR63

G protein-coupled receptor 63

chr17_+_73598139 3.146 MYO15B
myosin XVB pseudogene
chr19_-_50266514 3.120 NM_021733
TSKS
testis-specific serine kinase substrate
chr19_-_17958814 3.115 NM_000215
JAK3
Janus kinase 3
chr9_+_135937364 3.064 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr1_-_161193375 3.055 NM_001643
APOA2
apolipoprotein A-II
chr10_+_114136014 3.009 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_149754245 2.994 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr3_-_164914448 2.920 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr1_-_161193190 2.904 APOA2
apolipoprotein A-II
chr19_-_53758107 2.872 NM_182609
ZNF677
zinc finger protein 677
chrX_+_100333835 2.857 NM_021637
TMEM35
transmembrane protein 35
chr15_-_74500394 2.818 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr20_+_44650260 2.818 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_-_12677347 2.809 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr20_-_6034617 2.805 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr11_+_109292874 2.781 C11orf87
chromosome 11 open reading frame 87
chr19_+_41515495 2.769 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr16_+_86544104 2.735 NM_001451
FOXF1
forkhead box F1
chr8_-_93107881 2.700 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr1_+_160085519 2.687 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr11_+_125703210 2.630 NM_001144874
PATE4
prostate and testis expressed 4
chr11_+_36317724 2.629 NM_001160167
PRR5L
proline rich 5 like
chr11_-_35440514 2.627 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr19_-_36019194 2.619 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr13_-_46679143 2.609 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr15_+_82944821 2.605 AGSK1
golgin subfamily A member 2-like
chr19_-_16008870 2.593 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr20_+_3024267 2.576 NM_001501
NM_178331
NM_178332
GNRH2


gonadotropin-releasing hormone 2


chr15_+_82944772 2.516 AGSK1
golgin subfamily A member 2-like
chr13_+_52034639 2.505


chr19_-_44306525 2.471 NM_001031749
LYPD5
LY6/PLAUR domain containing 5
chr10_+_114135937 2.458 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr18_+_74961925 2.428 NM_001480
GALR1
galanin receptor 1
chr11_-_118095708 2.426 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr20_-_1638359 2.410 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chr1_+_153003677 2.410 NM_003125
SPRR1B
small proline-rich protein 1B
chr19_-_17958773 2.398 JAK3
Janus kinase 3
chr16_-_58005011 2.363 NM_001135639
NM_001297
CNGB1

cyclic nucleotide gated channel beta 1

chr3_-_193272587 2.357 NM_032279
ATP13A4
ATPase type 13A4
chr3_+_39509069 2.355 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr6_-_29395489 2.355 NM_013937
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr12_+_56075329 2.350 NM_152637
METTL7B
methyltransferase like 7B
chr19_+_46498338 2.343 NM_001080402
CCDC61
coiled-coil domain containing 61
chr2_+_234601511 2.234 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr7_-_81399286 2.202 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr10_+_50822082 2.200 NM_001142929
NM_001142933
NM_001142934
NM_020549
CHAT



choline O-acetyltransferase



chr10_+_123754141 2.186 TACC2
transforming, acidic coiled-coil containing protein 2
chr8_-_70747200 2.176 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr6_-_33714681 2.158 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr10_+_104590430 2.146


chr3_-_187420344 2.143 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr10_+_114135965 2.139 ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_-_46894380 2.131 NM_001130918
TTLL6
tubulin tyrosine ligase-like family, member 6
chr3_-_42917632 2.122 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_+_128872924 2.114 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr2_+_17721983 2.108 VSNL1
visinin-like 1
chr19_-_49944613 2.077 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr10_-_7659186 2.076 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr17_+_78161598 2.076 NM_052819
CARD14
caspase recruitment domain family, member 14
chr2_-_97563830 2.067 NM_016490
FAM178B
family with sequence similarity 178, member B
chr8_-_22785228 2.062 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr12_-_4488707 2.052 NM_020638
FGF23
fibroblast growth factor 23
chr3_-_46506342 2.036 NM_002343
LTF
lactotransferrin
chr9_+_42717233 2.032 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr9_-_125330755 1.986 NM_001004454
OR1L8
olfactory receptor, family 1, subfamily L, member 8
chr1_-_36851517 1.984 STK40
serine/threonine kinase 40
chr16_-_49860917 1.973 NM_015069
ZNF423
zinc finger protein 423
chr8_-_143999255 1.972 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chrY_-_1281526 1.969 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr19_+_38880839 1.968 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chrX_-_107225588 1.960 NM_031273
TEX13B
testis expressed 13B
chrX_-_153847390 1.947 NM_001327
NM_139250
CTAG1B
CTAG1A
cancer/testis antigen 1B
cancer/testis antigen 1A
chr16_-_28634873 1.946 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr8_-_95229530 1.922 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_+_203734283 1.908 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr1_-_36851484 1.901 NM_032017
STK40
serine/threonine kinase 40
chr19_+_46651499 1.899 NM_001135113
IGFL2
IGF-like family member 2
chr2_+_17721806 1.897 NM_003385
VSNL1
visinin-like 1
chrM_+_12283 1.896


chr6_+_36916038 1.891 NM_001199159
PI16
peptidase inhibitor 16
chr20_-_56100138 1.885 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr9_+_117904096 1.869 NM_017418
DEC1
deleted in esophageal cancer 1
chr19_-_51845377 1.858 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr3_+_115342302 1.858 GAP43
growth associated protein 43
chr12_-_323255 1.854 NM_001122848
NM_001206931
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr1_+_26644458 1.851 CD52
CD52 molecule
chr6_+_155585146 1.845 NM_001001346
CLDN20
claudin 20
chr19_-_42348507 1.836 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr11_-_6676851 1.835 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr12_-_125348346 1.830 SCARB1
scavenger receptor class B, member 1
chr10_+_50817140 1.829 NM_020984
CHAT
choline O-acetyltransferase
chr13_-_72441312 1.813 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr12_-_57328044 1.810 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chrX_-_119249774 1.804 NM_139282
RHOXF1
Rhox homeobox family, member 1
chr12_+_50497790 1.798 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr13_-_39564857 1.791 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr19_-_14064192 1.790 NM_001146254
NM_001146255
PODNL1

podocan-like 1

chr19_-_50169021 1.788 NM_001197122
NM_001197123
NM_001197124
NM_001197125
NM_001197126
NM_001197127
NM_001197128
NM_001571
IRF3







interferon regulatory factor 3







chr16_-_71610948 1.786 NM_000353
TAT
tyrosine aminotransferase
chr1_-_120935893 1.783 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chrX_+_148793737 1.766 NM_005366
MAGEA11
melanoma antigen family A, 11
chr22_-_22901421 1.761 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr2_-_220173693 1.760 NM_001199764
PTPRN
protein tyrosine phosphatase, receptor type, N
chr10_-_103603539 1.759 NM_014591
NM_173191
NM_173192
NM_173193
NM_173195
NM_173197
KCNIP2





Kv channel interacting protein 2





chr1_-_1310522 1.757 AURKAIP1
aurora kinase A interacting protein 1
chr12_-_53614121 1.744 NM_001042728
NM_001243732
RARG

retinoic acid receptor, gamma

chr4_+_152198324 1.730 NM_183375
PRSS48
protease, serine, 48
chr11_-_2158501 1.725


chr5_+_17217474 1.724 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr1_+_9352955 1.723 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr4_+_55523906 1.713 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr1_-_26197743 1.708 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr8_-_143833924 1.708 NM_205545
LYPD2
LY6/PLAUR domain containing 2
chrX_-_111326003 1.702 NM_012471
TRPC5
transient receptor potential cation channel, subfamily C, member 5
chr22_-_36600759 1.702 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr19_-_46405854 1.698 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr9_-_70429730 1.693 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr4_-_154681016 1.675


chr1_-_20445991 1.669 NM_012400
PLA2G2D
phospholipase A2, group IID
chr1_+_28585959 1.651 NM_031459
SESN2
sestrin 2
chrX_-_151286410 1.647 NM_021049
MAGEA5
melanoma antigen family A, 5
chr7_-_104567089 1.642 LOC723809
uncharacterized LOC723809
chr19_-_50432952 1.641 NM_016553
NUP62
nucleoporin 62kDa
chr12_-_9268513 1.639 A2M
alpha-2-macroglobulin
chr16_+_76311175 1.625 NM_033401
CNTNAP4
contactin associated protein-like 4
chr12_+_56075418 1.623 METTL7B
methyltransferase like 7B
chr15_-_26108869 1.622 ATP10A
ATPase, class V, type 10A
chr14_-_94443065 1.610 NM_001202429
ASB2
ankyrin repeat and SOCS box containing 2
chr22_-_37608352 1.603 NM_001051
SSTR3
somatostatin receptor 3
chrX_-_130423387 1.603 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr12_-_125348266 1.601 SCARB1
scavenger receptor class B, member 1
chr9_-_70178814 1.597 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr14_+_20978611 1.596 NM_001012975
RNASE10
ribonuclease, RNase A family, 10 (non-active)
chr7_-_4998744 1.594 NM_001100600
NM_198403
MMD2

monocyte to macrophage differentiation-associated 2

chr5_-_22853730 1.593 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr7_-_141541220 1.580 NM_001008270
NM_001171951
PRSS37

protease, serine, 37

chr7_-_150721551 1.578 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr1_+_198608244 1.578 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_19619878 1.575 NM_001099646
NM_152908
SLC47A2

solute carrier family 47, member 2

chr21_-_28339405 1.573 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr3_-_133648517 1.567 NM_025041
C3orf36
chromosome 3 open reading frame 36
chr17_-_41984888 1.565 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr1_-_120935943 1.562 NM_001004340
NM_001017986
NM_001244910
FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr12_-_125348422 1.558 NM_001082959
NM_005505
SCARB1

scavenger receptor class B, member 1

chr3_-_121379757 1.550 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chrX_+_27764925 1.550 NM_001136533
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr13_+_29598746 1.548 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr12_-_8218930 1.547 NM_004054
C3AR1
complement component 3a receptor 1
chr12_-_56101465 1.535 ITGA7
integrin, alpha 7
chr11_+_72983246 1.533 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr17_+_46970128 1.525 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr14_-_23284565 1.523 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr15_-_74502045 1.518 NM_001199040
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr1_-_163113129 1.509 RGS5
regulator of G-protein signaling 5
chr20_-_44455932 1.506 NM_003279
TNNC2
troponin C type 2 (fast)
chr6_+_31554975 1.504 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr19_+_50354417 1.500 PTOV1
prostate tumor overexpressed 1
chr9_-_33395265 1.498 AQP7
aquaporin 7
chr9_+_35673852 1.493 NM_001216
CA9
carbonic anhydrase IX
chr19_-_50168866 1.491 IRF3
interferon regulatory factor 3
chr8_-_93107442 1.491 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr18_-_31019981 1.487 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr17_-_41985112 1.487 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr12_-_11422640 1.480 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr19_+_54057898 1.472 NM_001253801
ZNF331
zinc finger protein 331
chr19_+_59055866 1.464 TRIM28
tripartite motif containing 28
chr15_+_82647307 1.458 UBE2Q2P2
ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 2
chr1_+_203444882 1.449 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.89 1.82e-03 GO:0042221 response to chemical stimulus
16.62 8.72e-03 GO:0006706 steroid catabolic process
4.15 1.51e-02 GO:0008202 steroid metabolic process
5.25 1.94e-02 GO:0006805 xenobiotic metabolic process
5.25 1.94e-02 GO:0071466 cellular response to xenobiotic stimulus
5.21 2.07e-02 GO:0009410 response to xenobiotic stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.49 1.75e-04 GO:0031224 intrinsic to membrane
1.38 1.80e-03 GO:0044425 membrane part
1.51 3.60e-03 GO:0005886 plasma membrane
1.42 4.92e-03 GO:0016021 integral to membrane
1.49 6.23e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
17.45 1.64e-02 GO:0008395 steroid hydroxylase activity
6.11 3.71e-02 GO:0004497 monooxygenase activity